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Brian B. Gowen
Research Associate Professor

Research Interests

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  Publications

  1. Gowen, B.B., Borg, T.K., Ghaffar, A. and Mayer, E.P.  Selective adhesion of macrophages to denatured forms of type I collagen is mediated by scavenger receptors. Matrix Biol. (2000) 19, 61-71.

  2. Gowen, B.B., Borg, T.K., Ghaffar, A. and Mayer, E.P.  The collagenous domain of class A scavenger receptors is involved in macrophage adhesion to collagens.  J. Leukoc. Biol. (2001) 69, 575-82.

  3. Hoe, N.P., Ireland, R.M., Deleo, F.R., Gowen, B.B., Dorward, D.W., Voyich, J.M., Liu, M., Burns, Jr., E.H., Culnan, D.M., Bretscher, A. and Musser, J.M.  Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells.  Proc. Nat. Acad. Sci. USA (2002) 99, 7646-51.

  4. Rebeil, R., Ernst, R.K., Gowen, B.B., Miller, S.I. and Hinnebusch, B.J.  Variation in lipid A structure in the pathogenic yersiniae.  Mol. Microbiol. (2004) 52, 1363-73.

  5. Graham, M.R., Virtaneva K., Porcella, S.F., Barry, W.T., Gowen, B.B., Johnson, C.A., Wright, F.A. and Musser, J.M.  Group A Streptococcus transcriptome dynamics during growth in human blood reveals bacterial adaptive and survival strategies. Am. J. Pathol. (2005) 166, 455-65.

  6. Sebbane, F., Gardner, D., Long, D., Gowen, B.B. and Hinnebusch, B.J.  Kinetics of disease progression and host response in a rat model of bubonic plague. Am. J. Pathol. (2005) 166, 1427-39.

  7. Gowen, B.B., Barnard, D.L., Smee, D.F., Wong, M., Pace, A.M., Jung, K., Winslow, S.G., Bailey, K.W., Blatt, L.M. and Sidwell, R.W.  Interferon alfacon-1 protects hamsters from lethal Pichinde virus infection.  Antimicrob. Agents Chemother. (2005) 49, 2378-86.

  8. Gowen, B.B., Fairman, J., Smee, D.F., Wong, M., Jung, K., Pace, A.M., Heiner, M.L., Bailey, K.W., Dow, S.W. and Sidwell, R.W.  Protective immunity against acute phleboviral infection elicited through immunostimulatory cationic liposome-DNA complexes.  Antiviral Res. (2006) 69, 165-72.

  9. Gowen, B.B., Smee, D.F., Wong, M., Judge, J.W., Jung, K., Bailey, K.W., Pace, A.M., Rosenberg, B. and Sidwell, R.W.  Recombinant Eimeria protozoan protein elicits resistance to acute phlebovirus infection in mice but not hamsters.  Antimicrob. Agents Chemother. (2006) 50, 2023-9.

  10. Gowen, B.B., Smee, D.F., Wong, M., Pace, A.M., Jung, K., Bailey, K.W., Blatt, L.M. and Sidwell, R.W.  Combinatorial ribavirin and interferon alfacon-1 therapy of acute arenaviral disease in hamsters.  Antivir. Chem. Chemother. (2006) 17, 175-83.

  11. Gowen, B.B., Hoopes, J.D., Wong, M., Jung, K., Isakson, K.C., Alexopoulou, L., Flavell, R.A. and Sidwell, R.W.  TLR3 deletion limits mortality and disease severity due to phlebovirus infection.  J. Immunol. (2006) 177, 6301-7.

  12. Gowen, B.B., Wong, M., Jung, K., Mitchell, W.M., Sanders, A.B, Alexopoulou, L., Flavell, R.A. and Sidwell, R.W.  TLR3 is essential for the induction of protective immunity against Punta Toro virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not poly(I:C):  Differential recognition of synthetic dsRNA molecules.  J. Immunol. (2007) 178, 5200-8.

  13. Gowen, B.B., Wong, M., Jung, K., Sanders, A.B., Mendenhall, M., Bailey, K.W., Furuta, Y. and Sidwell, R.W.  In vitro and in vivo activity of T-705 against arenavirus and bunyavirus infections. Antimicrob. Agents Chemother. (2007) 51, 3168-76.

  14. Selvam, P., Vijayalakshimi, B., Smee, D.F., Gowen, B.B., Julander, J.G., Day, C.W. and Barnard, D.L.  Novel-3-sulphonamido-quinazolin-4(3H)-one derivatives: microwave-assisted synthesis and evaluation of anti-viral activities against respiratory and biodefense viruses.  Antivir. Chem. Chemother. (2007) 18, 301-5.

  15. Ma, X., Liu, Y. Gowen, B.B., Graviss, E.A., Clark, A.G. and Musser, J.M.  Full-exon sequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease. PLoS ONE. (2007) 2, e1318.

  16. Holbrook, M.R. and Gowen, B.B. Animal models of highly pathogenic RNA viral infections: Encephalitis viruses.  Antiviral Res. (2008) 78, 69-78.

  17. Gowen, B.B. and Holbrook, M.R. Animal models of highly pathogenic RNA viral infections: Hemorrhagic fever viruses. Antiviral Res. (2008) 78, 79-90.

  18. Smee, D.F., Gowen, B.B., Wandersee, M.K., Wong, M., Skirpstunas, R.T., Baldwin, T.J.,  Hoopes, J.D. and Sidwell, R.W.  Differential pathogenesis of cowpox virus intranasal infections in mice induced by low and high inoculum volumes, and effects of cidofovir treatment.  Int. J. Antimicrob. Agents. (2008) 31, 352-9.

  19. Gowen, B.B., Wong, M., Jung, K., Blatt, L.M. and Sidwell, R.W.  Prophylactic and therapeutic intervention of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with Interferon Alfacon-1.  Antiviral Res. (2008) 77, 215-24.

  20. Gowen, B.B., Judge, J.W., Wong, M.H., Jung, K.H., Aylsworth, C.F., Melby, P.C., Rosenberg, B. and Morrey, J.D.  Immunoprophylaxis of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with recombinant Eimeria profilin-like antigen. Int. Immunopharmacol. (2008) 8, 1089-94.

  21. Subramanian, G.M., Moore, P.A., Gowen, B.B., Olsen, A.L., Barnard, D.L., Paragas, J., Hogan, R.J. and Sidwell, R.W.  Potent in vitro activity of the albumin fusion type 1 interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agents of bioterrorism and the severe acute respiratory syndrome (SARS) virus.  Chemotherapy (2008) 54, 176-80.

  22. Gowen, B.B., Smee, D.F., Wong, M., Hall, J.O., Jung, K., Bailey, K.W., Stevens, J.R., Furuta, Y. and Morrey, J.D.  Treatment of late stage disease in a model of arenaviral hemorrhagic fever:  T-705 efficacy and reduced toxicity suggests a viable alternative to ribavirin therapy.  PLoS ONE (2008) 3, e3725.

  23. Gowen, B.B., Fairman, J., Dow, S.W., Troyer, R., Wong, M., Jung, K., Melby, P.C. and Morrey, J.D.  Prophylaxis with cationic liposome-DNA complexes protects hamsters from phleboviral disease:  importance of liposomal delivery and CpG motifs.  Antiviral Res. (2009) 81, 37-46.

  24. Furuta, Y., Takahashi, K., Shiraki, K., Sakamoto, K., Smee, D.F., Barnard, D.L., Gowen, B.B., Julander, J.G., and Morrey, J.D. T-705 (favipiravir) and related compounds:  Novel broad-spectrum inhibitors of RNA viral infections.  Antiviral Res. (2009) 83, 95-102.

  25. Duran, N., Gowen, B.B., Costa, F.T., Justo, G.Z., Brocchi, M., Nunes, O.S. and Nunes, I.S.  A biotechnological product and its potential as a new immunomodulator for treatment of animal phlebovirus infection: Punta Toro virus.  Antiviral Res. (2009) 83, 143-7.

  26. Mendenhall, M., Wong, M.H., Skirpstunas, R., Morrey, J.D. and Gowen, B.B. Punta Toro virus (Bunyaviridae, Phlebovirus) infection in mice: strain differences in pathogenesis and host interferon response. Virology (2009) 395, 143-51.

  27. Gowen, B.B., Wong, M.H., Jung, K.H., Smee, D.F., Morrey, J.D. and Furuta, Y. Efficacy of favipiravir (T-705) and T-1106 pyrazine derivatives in phlebovirus disease models. Antiviral Res. (2010) 86, 121-7.

  28. Gowen, B.B., Wong, M.H., Larson, D., Ye, W., Jung, K.H., Sefing, E.J., Skirpstunas, R., Smee, D.F., Morrey, J.D. and Schneller, S.W. Development of a new Tacaribe arenavirus infection model and its use to explore antiviral activity of a novel aristeromycin analog. PLoS ONE (2010) 5, pii: e12760.

  29. Gowen, B.B., Julander, J.G., London, N.R., Wong, M.H., Larson, D., Morrey, J.D., Li, D.Y. and Bray, M. Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever. Virol. J. (2010) 7, 240.

  30. Mendenhall, M., Russell, A., Juelich, T., Messina, E.L., Smee, D.F., Freiberg, A.N., Holbrook, M.R., Furuta, Y., de la Torre, J.C., Nunberg, J.H. and Gowen, B.B. T-705 (Favipiravir) inhibition of arenavirus replication in cell culture. Antimicrob. Agents Chemother. (2011) 55, 782-7.

  31. Buys, K.K., Jung, K.H., Smee, D.F., Furuta, Y., Gowen, B.B. Favipiravir (T-705) inhibits Maporal and Dobrava hantavirus infection in Vero E6 cells. Submitted to Antivir. Chem. and Chemother.(2011) 21, 193-200.

  32. Mendenhall, M., Russell, A., Smee, D.F., Hall, J.O., Skirpstunas, R., Furuta, Y., Gowen, B.B. Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic fever. Submitted to PLoS Negl. Trop. Dis. (2011), In press.

  33. Gowen, B.B., Ennis, J., Russell, A., Sefing, E.J., Wong, M.H., Turner, J. Use of recombinant adenovirus vectored consensus IFN- α to avert severe arenavirus infection. PLoS ONE (2011), e26072.

  34. Gowen, B.B., Bray, M. Progress in the experimental therapy of severe arenaviral infections. Future Microbiol. (2011) 6, 1429-41.

  35. Gowen, B.B., Ennis, J., Sefing, E.J., Wong, M.H., Jung, K.H., Turner, J.D. Extended protection against phlebovirus infection conferred by recombinant adenovirus expressing consensus interferon (DEF201). Antimicrob. Agents Chemother. (2012) May 21 Epub ahead of print.