In Vivo Antiviral Testing

We are happy to test your antiviral compounds in animal models.
The I.A.R. routinely performs testing for antiviral efficacy in vivo. We have a myriad of viruses available, including BSL-3, BSL-3+, and select agents such as pandemic influenza, SARS, MERS, dengue fever, yellow fever, and West Nile virus. Models include BALB/c mice, trangenic mice, hamsters, ferrets, and specialty mouse strains. We have state-of-the-art methods to evaluate antiviral efficacy and disease signs, including plethismography. Please contact Dr. Craig Day (435-512-1592, craig.day@usu.edu) for details and pricing.

Below is a list of many of the viruses we have readily available for in vivo screening:

Virus family

Pathogen

Host species

Model for human disease/condition

Arenaviridae

Pichinde virus

hamster and guinea pig

arenaviral hemorrhagic fever

Tacaribe virus

AG129 mouse

arenaviral infection

Junin virus

guinea pig and AG129 mouse

Argentine hemorrhagic fever

Bunyaviridae

Punta Toro virus

mouse and hamster

Rift Valley fever

Rift Valley fever

mouse and hamster

Rift Valley fever

Coronaviridae

SARS coronavirus

mouse

acute respiratory distress syndrome

Flaviviridae

West Nile virus

mouse and hamster

encephalitis

Banzi virus

mouse

encephalitis

Dengue virus

AG129 mouse

dengue fever/dengue hemorrhagic fever

Yellow fever virus

hamster

yellow fever

Hepadnaviridae

Hepatitis B virus

mouse

hepatitis B in liver and serum

Herpesviridae

Type 1 or 2 herpes

mouse

encephalitis

Type 1 herpes

mouse

cutaneous infections

Type 2 herpes genitalis

mouse

genital infection

Cytomegalovirus

mouse

systemic infection

Murine herpes virus-68

mouse

EB virus-like disease

Orthomyxoviridae

Influenza A (H1N1 seasonal)

mouse

pneumonia

Influenza A (H1N1 seasonal) oseltamivir-resistant

mouse

pneumonia

Influenza A (H1N1 pandemic)

mouse

pneumonia

Influenza A (H1N1 pandemic)
oseltamivir-resistant

mouse

pneumonia

Influenza A (H3N2 seasonal)

mouse

pneumonia

Influenza A (H1N1 low pathogenic avian)

mouse

pneumonia

Influenza A (highly pathogenic avian)

mouse

pneumonia

Picornaviridae

Poliovirus

mouse

poliomyelitis

Poxviridae

Cowpox and vaccinia virus

mouse

pneumonia with systemic infection

Cowpox and vaccinia virus

mouse

cutaneous infections

Togaviridae

Semliki Forest virus

mouse

encephalitis

Western equine encephalitis virus

mouse

encephalitis

Venezuelan equine encephalitis virus

mouse

encephalitis

N/A

Prion

mouse

transmissible spongiform encephalopathy

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