In Vivo Antiviral Testing

The IAR routinely evaluates antiviral efficacy using in vivo models. We have a large selection of viruses and models available, including BSL-3, BSL-3+, and select agent viruses. The viruses listed below have been well-characterized in each of the specific animals. We have decades of experience evaluating antiviral efficacy, immune responses to viral infection, pharmacokinetic studies, cytokine and biomarkers of viral disease, and maximum tolerated dose studies. Please contact Michelle Mendenhall (michelle.mendenhall@usu.edu) or Dr. Brett Hurst (brett.hurst@usu.edu) for details and pricing. Below is a description of the animal models available for in vivo screening:

Arenaviridae

Pathogen	Host Species	Model for Human Disease/Condition	Reference
Pichinde virus	hamster and guinea pig	arenaviral hemorrhagic fever	Mendenhall et al. 2011
Tacaribe virus	mouse	arenaviral infection	Gowen et al. 2010
Junin virus	guinea pig and mouse	Argentine hemorrhagic fever	Gowen et al. 2017
Lymphocytic choriomeningitis virus	mouse	Old World arenavirus hemorrhagic fever	Hickerson et al. 2018

Coronaviridae

Pathogen	Host Species	Model for Human Disease/Condition	Reference
SARS coronavirus	mouse	acute respiratory distress syndrome	Day et al. 2009

Flaviviridae

Pathogen	Host Species	Model for Human Disease/Condition	Reference
West Nile virus	mouse and hamster	encephalitis and paralysis	Morrey et al. 2008
Banzi virus	mouse	encephalitis	Julander et al. 2007
Dengue virus	AG129 mouse	dengue fever/dengue hemorrhagic fever	Julander, Perry, and Shresta 2011
Usutu virus	AG129 mouse	encephalitis	In progress
Yellow fever virus	hamster	Yellow fever	Julander et al. 2014
Zika virus	AG129 mouse	encephalitis	Julander et al. 2017

Hepadnaviridae

Pathogen	Host Species	Model for Human Disease/Condition	Reference
Hepatitis B virus	mouse	hepatitis B in liver and serum	Morrey et al. 2009

Orthomyxoviridae

Pathogen	Host Species	Model for Human Disease/Condition	Reference
Influenza A (H1N1 seasonal)	mouse	pneumonia	Smee et al. 2016
Influenza A (H1N1 seasonal) oseltamivir-resistant	mouse	pneumonia	Smee et al. 2013
Influenza A (H1N1 pandemic)	mouse	pneumonia	Smee et al. 2013
Influenza A (H1N1 pandemic) oseltamivir-resistant	mouse	pneumonia	Smee et al. 2012
Influenza A (H3N2 seasonal)	mouse	pneumonia	Smee et al. 2016
Influenza A (H5N1 low pathogenic avian)	mouse	pneumonia	Smee et al. 2010
Influenza A (H5N1 high pathogenic avian)	mouse	pneumonia	Kumaki et al. 2011
Influenza A (H7N9)	mouse	pneumonia	Tharakaraman et al. 2015
Influenza B (Victoria lineage)	mouse	pneumonia	In progress
Influenza B (Yamagata lineage)	mouse	pneumonia	Warfield et al. 2016

Phenuiviridae

Pathogen	Host Species	Model for Human Disease/Condition	Reference
Punta Toro	mouse and hamster	Rift Valley Fever	Gowen et al. 2010
Rift Valley Fever	mouse and hamster	Rift Valley Fever	Smee et al. 2018
Severe fever w/thrombocytopenia syndrome	mouse and hamster	severe fever with thrombocytopenia syndrome	Smee et al. 2016
Heartland virus	mouse and hamster	Heartland virus disease	Westover et al. 2017

Picornaviridae

Pathogen	Host Species	Model for Human Disease/Condition	Reference
Coxsackievirus B3	mouse	myocarditis	In progress
Enterovirus D68	AG129 mouse	respiratory disease, neurological disease	Evans et al. 2018, Hurst et al. 2018
Enterovirus 71	AG129 mouse	neurological disease	In progress
Poliovirus	mouse	poliomyelitis	In progress

Poxviridae

Pathogen	Host Species	Model for Human Disease/Condition	Reference
Cowpox and vaccinia virus	mouse	pneumonia with systemic infection	Smee et al. 2013
Cowpox and vaccinia virus	mouse	cutaneous infection	Smee et al. 2015

Togaviridae

Pathogen	Host Species	Model for Human Disease/Condition	Reference
Chikungunya	mouse and hamster	joint swelling	Dagley and Julander, 2013
Eastern equine encephalitis	mouse and hamster	encephalitis	In progress
Semliki Forest	mouse	encephalitis	In progress
Western equine encephalitis	mouse	encephalitis	Julander et al. 2009
Venezuelan equine encephalitis	mouse	encephalitis	Julander et al. 2008