In Vivo Antiviral Testing
The IAR routinely evaluates antiviral efficacy using in vivo models. We have a large selection of viruses and models available, including BSL-3, BSL-3+, and select agent viruses. The viruses listed below have been well-characterized in each of the specific animals. We have decades of experience evaluating antiviral efficacy, immune responses to viral infection, pharmacokinetic studies, cytokine and biomarkers of viral disease, and maximum tolerated dose studies. Please contact Michelle Mendenhall (michelle.mendenhall@usu.edu) or Dr. Brett Hurst (brett.hurst@usu.edu) for details and pricing. Below is a description of the animal models available for in vivo screening:
Arenaviridae
Pathogen |
Host Species |
Model for Human Disease/Condition |
Reference |
Pichinde virus |
hamster and guinea pig |
arenaviral hemorrhagic fever |
Mendenhall et al. 2011 |
Tacaribe virus |
mouse |
arenaviral infection |
Gowen et al. 2010 |
Junin virus |
guinea pig and mouse |
Argentine hemorrhagic fever |
Gowen et al. 2017 |
Lymphocytic choriomeningitis virus |
mouse |
Old World arenavirus hemorrhagic fever |
Hickerson et al. 2018 |
Coronaviridae
Pathogen |
Host Species |
Model for Human Disease/Condition |
Reference |
SARS coronavirus |
mouse |
acute respiratory distress syndrome |
Day et al. 2009 |
Flaviviridae
Hepadnaviridae
Pathogen |
Host Species |
Model for Human Disease/Condition |
Reference |
Hepatitis B virus |
mouse |
hepatitis B in liver and serum |
Morrey et al. 2009 |
Orthomyxoviridae
Phenuiviridae
Pathogen |
Host Species |
Model for Human Disease/Condition |
Reference |
Punta Toro |
mouse and hamster |
Rift Valley Fever |
Gowen et al. 2010 |
Rift Valley Fever |
mouse and hamster |
Rift Valley Fever |
Smee et al. 2018 |
Severe fever w/thrombocytopenia syndrome |
mouse and hamster |
severe fever with thrombocytopenia syndrome |
Smee et al. 2016 |
Heartland virus |
mouse and hamster |
Heartland virus disease |
Westover et al. 2017 |
Picornaviridae
Pathogen |
Host Species |
Model for Human Disease/Condition |
Reference |
Coxsackievirus B3 |
mouse |
myocarditis |
In progress |
Enterovirus D68 |
AG129 mouse |
respiratory disease, neurological disease |
Evans et al. 2018, Hurst et al. 2018 |
Enterovirus 71 |
AG129 mouse |
neurological disease |
In progress |
Poliovirus |
mouse |
poliomyelitis |
In progress |
Poxviridae
Pathogen |
Host Species |
Model for Human Disease/Condition |
Reference |
Cowpox and vaccinia virus |
mouse |
pneumonia with systemic infection |
Smee et al. 2013
|
Cowpox and vaccinia virus |
mouse |
cutaneous infection |
Smee et al. 2015
|
Togaviridae
Pathogen |
Host Species |
Model for Human Disease/Condition |
Reference |
Chikungunya |
mouse and hamster |
joint swelling |
Dagley and Julander, 2013
|
Eastern equine encephalitis |
mouse and hamster |
encephalitis |
In progress |
Semliki Forest |
mouse |
encephalitis |
In progress |
Western equine encephalitis |
mouse |
encephalitis |
Julander et al. 2009
|
Venezuelan equine encephalitis |
mouse |
encephalitis
|
Julander et al. 2008
|