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In Vivo Antiviral Testing

The IAR routinely evaluates antiviral efficacy using in vivo models. We have a large selection of viruses and models available, including BSL-3, BSL-3+, and select agent viruses.  The viruses listed below have been well-characterized in each of the specific animals.  We have decades of experience evaluating antiviral efficacy, immune responses to viral infection, pharmacokinetic studies, cytokine and biomarkers of viral disease, and maximum tolerated dose studies.  Please contact Michelle Mendenhall (michelle.mendenhall@usu.edu) or Dr. Brett Hurst (brett.hurst@usu.edu) for details and pricing. Below is a description of the animal models available for in vivo screening:


Arenaviridae

Pathogen Host Species Model for Human Disease/Condition Reference
Pichinde virus hamster and guinea pig arenaviral hemorrhagic fever Mendenhall et al. 2011
Tacaribe virus mouse arenaviral infection Gowen et al. 2010
Junin virus guinea pig and mouse Argentine hemorrhagic fever Gowen et al. 2017
Lymphocytic choriomeningitis virus mouse Old World arenavirus hemorrhagic fever Hickerson et al. 2018

 Coronaviridae

Pathogen Host Species Model for Human Disease/Condition Reference
SARS coronavirus mouse acute respiratory distress syndrome Day et al. 2009

 Flaviviridae

Pathogen Host Species Model for Human Disease/Condition Reference
West Nile virus mouse and hamster encephalitis and paralysis Morrey et al. 2008
Banzi virus mouse encephalitis Julander et al. 2007
Dengue virus AG129 mouse dengue fever/dengue hemorrhagic fever Julander, Perry, and Shresta 2011
Usutu virus AG129 mouse encephalitis In progress
Yellow fever virus hamster Yellow fever Julander et al. 2014
Zika virus AG129 mouse encephalitis Julander et al. 2017

 Hepadnaviridae

Pathogen Host Species Model for Human Disease/Condition Reference
Hepatitis B virus mouse hepatitis B in liver and serum Morrey et al. 2009

 Orthomyxoviridae

Pathogen Host Species Model for Human Disease/Condition Reference
Influenza A (H1N1 seasonal) mouse pneumonia Smee et al. 2016
Influenza A (H1N1 seasonal) oseltamivir-resistant mouse pneumonia Smee et al. 2013 
Influenza A (H1N1 pandemic) mouse pneumonia Smee et al. 2013 
Influenza A (H1N1 pandemic) oseltamivir-resistant mouse  pneumonia Smee et al. 2012 
Influenza A (H3N2 seasonal)  mouse  pneumonia  Smee et al. 2016
Influenza A (H5N1 low pathogenic avian)  mouse  pneumonia  Smee et al. 2010 
Influenza A (H5N1 high pathogenic avian)  mouse  pneumonia  Kumaki et al. 2011 
Influenza A (H7N9) mouse pneumonia Tharakaraman et al. 2015 
Influenza B (Victoria lineage) mouse pneumonia In progress 
Influenza B (Yamagata lineage) mouse pneumonia Warfield et al. 2016 

 Phenuiviridae

Pathogen Host Species Model for Human Disease/Condition Reference
Punta Toro  mouse and hamster Rift Valley Fever Gowen et al. 2010
Rift Valley Fever mouse and hamster Rift Valley Fever Smee et al. 2018
Severe fever w/thrombocytopenia syndrome mouse and hamster severe fever with thrombocytopenia syndrome Smee et al. 2016
Heartland virus mouse and hamster Heartland virus disease Westover et al. 2017

 Picornaviridae

Pathogen Host Species Model for Human Disease/Condition Reference
Coxsackievirus B3 mouse myocarditis In progress
Enterovirus D68 AG129 mouse respiratory disease, neurological disease Evans et al. 2018Hurst et al. 2018
Enterovirus 71 AG129 mouse neurological disease In progress
Poliovirus mouse poliomyelitis In progress

Poxviridae 

Pathogen Host Species Model for Human Disease/Condition Reference
Cowpox and vaccinia virus mouse pneumonia with systemic infection Smee et al. 2013 
Cowpox and vaccinia virus mouse cutaneous infection Smee et al. 2015 

 Togaviridae

Pathogen Host Species Model for Human Disease/Condition Reference
Chikungunya mouse and hamster joint swelling Dagley and Julander, 2013 
Eastern equine encephalitis mouse and hamster encephalitis In progress 
Semliki Forest mouse encephalitis In progress 
Western equine encephalitis mouse encephalitis Julander et al. 2009 
Venezuelan equine encephalitis mouse encephalitis  Julander et al. 2008